General Information

  • ID:  hor004378
  • Uniprot ID:  P62933
  • Protein name:  Eledoisin
  • Gene name:  NA
  • Organism:  Eledone cirrhosa (Curled octopus) (Ozaena cirrosa)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eledone (genus), Octopodidae (family), Incirrata (suborder), Octopoda (order), Octopodiformes (superorder), Coleoidea (subclass), Cephalopoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QPSKDAFIGLM
  • Length:  11(1-11)
  • Propeptide:  QPSKDAFIGLM
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T11 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q91W27-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-Q91W27-F1.pdbhor004378_AF2.pdbhor004378_ESM.pdb

Physical Information

Mass: 138498 Formula: C54H87N13O16S
Absent amino acids: CEHNRTVWY Common amino acids: ADFGIKLMPQS
pI: 6.34 Basic residues: 1
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 10 Boman Index: -529
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 80
Instability Index: 4410.91 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  14012712
  • Title:  The Isolation and Amino Acid Sequence of Eledoisin, the Active Endecapeptide of the Posterior Salivary Glands of Eledone